Please use this identifier to cite or link to this item: https://research.matf.bg.ac.rs/handle/123456789/1379
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dc.contributor.authorVasović, Lazar Men_US
dc.contributor.authorPavlović-Lažetić, Gordana Men_US
dc.contributor.authorKovačević, Jovanaen_US
dc.contributor.authorBeljanski, Miloš Ven_US
dc.contributor.authorUversky, Vladimir Nen_US
dc.date.accessioned2024-10-25T14:41:23Z-
dc.date.available2024-10-25T14:41:23Z-
dc.date.issued2023-11-22-
dc.identifier.issn07302312-
dc.identifier.urihttps://research.matf.bg.ac.rs/handle/123456789/1379-
dc.descriptionThis is the peer reviewed version of the following article: Vasović LM, Pavlović-Lažetić GM, Kovačević JJ, Beljanski MV, Uversky VN. Intrinsically disordered proteins and liquid–liquid phase separation in SARS-CoV-2 interactomes. J Cell Biochem. 2023; 1-13. doi:10.1002/jcb.30502, which has been published in final form at <a href="https://dx.doi.org/10.1002/jcb.30502">10.1002/jcb.30502</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.en_US
dc.description.abstractThis paper discusses the properties of proteins and their relations in the interactomes of the selected subsets of SARS-CoV-2 proteome-the membrane protein, nonstructural proteins, and, finally, full proteome. Protein disorder according to several measures, liquid-liquid phase separation probabilities, and protein node degrees in the interaction networks were singled out as the features of interest. Additionally, viral interactomes were combined with the interactome of human lung tissue so as to examine if the new connections in the resulting viral-host interactome are linked to protein disorder. Correlation analysis shows that there is no clear relationship between raw features of interest, whereas there is a positive correlation between the protein disorder and its neighborhood mean disorder. There are also indications that highly connected viral hubs tend to be on average more ordered than proteins with a small number of connections. This is in contrast to previous similar studies conducted on eukaryotic interactomes and possibly raises new questions in research on viral interactomes.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of cellular biochemistryen_US
dc.subjectSARS-CoV-2en_US
dc.subjectcorrelation analysisen_US
dc.subjectinteractomicsen_US
dc.subjectintrinsically disordered proteins (IDPs)en_US
dc.subjectintrinsically disordered regions (IDRs)en_US
dc.subjectliquid-liquid phase separation (LLPS)en_US
dc.subjectviral-host interactomesen_US
dc.titleIntrinsically disordered proteins and liquid-liquid phase separation in SARS-CoV-2 interactomesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jcb.30502-
dc.identifier.pmid37992221-
dc.identifier.scopus2-s2.0-85177593719-
dc.identifier.isi001109486100001-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85177593719-
dc.contributor.affiliationInformatics and Computer Scienceen_US
dc.relation.issn0730-2312en_US
dc.description.rankM22en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairetypeArticle-
crisitem.author.deptInformatics and Computer Science-
crisitem.author.orcid0000-0002-0242-2472-
Appears in Collections:Research outputs
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